The Antidote: A Novel

Karen Russell‘s The Antidote, a finalist in the fiction category for the 2025 National Book Award, serves as a profound reckoning with a nation’s tendency to forget. It addresses the settler amnesia and deliberate omissions that have been passed down through generations, revealing not only horrors but also shimmering possibilities. The Antidote resonates with urgent warnings about our current climate emergency, prompting readers to reflect on what might have been and what is still possible.

The Antidote opens on Black Sunday, as a historic dust storm ravages the fictional town of Uz, Nebraska. But Uz is already collapsing—not just under the weight of the Great Depression and the Dust Bowl drought but beneath its own violent histories.

The Antidote follows a “Prairie Witch,” whose body serves as a bank vault for peoples’ memories and secrets; a Polish wheat farmer who learns how quickly a hoarded blessing can become a curse; his orphan niece, a basketball star and witch’s apprentice in furious flight from her grief; a voluble scarecrow; and a New Deal photographer whose time-traveling camera threatens to reveal both the town’s secrets and its fate.

Karen Russell is the author of six fiction books, including the New York Times bestsellers Swamplandia! and Vampires in the Lemon Grove. She is a MacArthur Fellow, a Guggenheim Fellow, and a Pulitzer Prize finalist.

She has received two National Magazine Awards for Fiction, the Shirley Jackson Award, the 2023 Bottari Lattes Grinzane Prize, and the 2024 Mary McCarthy Prize, and was selected for the National Book Foundation’s 5 Under 35 award and The New Yorker’s 20 Under 40 list (she is now decisively over forty).

She serves on the board of Street Books, a mobile library for people living outdoors. Born and raised in Miami, Florida, she lives in Portland, Oregon, with her husband, son, and daughter.

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